Latest Publications

A Randomized Trial of Single-Dose Oral Dexamethasone Versus Multidose Prednisolone for Acute Exacerbations of Asthma in Children Who Attend the Emergency Department

by John J. Cronin, MB, AFRCSI, Siobhan McCoy, RGN, RCN, Una Kennedy, FRCEM, Sinéad Nic an Fhailí, PhD, MICR, Abel Wakai, MD, FRCEM, John Hayden, BPharm, Gloria Crispino, PhD, CStat, Michael J. Barrett, MB, MRCPI, Sean Walsh, FRCEM, Ronan O’Sullivan, FPAEDS, MBA, October, 2015

In acute exacerbations of asthma in children, corticosteroids reduce relapses, subsequent hospital admission, and the need for ß2-agonist bronchodilators. 

Respiratory Syncytial Virus Preterm (32-36 Completed Weeks Gestation) Risk Estimation Measure for RSV Hospitalization in Ireland: A Prospective Study

by Sheridan-Pereira, Margaret FRCPI; Murphy, Joan PhD; Sloan, Julie R.M; Crispino, Gloria PhD; Leahy, Anne FRCPI; Corcoran, J David FRCPI; Dempsey, Eugene FRCPI; Elnazir, Basil FRCPI; Gavin, Patrick FRCPI; Sharif, Farhana FRCPI; Gul, Rizwan FRCPI; Satas, Salius PhD; Murphy, John FRCPI; Gormally, Siobhan FRCPI; Shanaa, Issam FRCPI; Waldron, David FRCPI; Mc Mahon, Paul FRCPI; Carson, John FRCPI; Blanken, Maarten; Bont, Louis MD, PhD; Paes, Bosco FRCPC, October, 2015

In several countries RSV prophylaxis is offered to late preterm infants who are at escalated risk of respiratory syncytial virus hospitalization (RSVH). 

The Acoustic Features of Inhalation can be Used to Quantify Aerosol Delivery from a Diskus™ Dry Powder Inhaler

by Jansen N Seheult, P O'Connell, Kee Chun Tee, T Bholah, H Al Bannai, I Sulaiman, E MacHale, S D'Arcy, MS Holmes, D Bergin, E Reeves, RB Reilly, G Crispino-O'Connell, C Ehrhardt, A Healy, RW Costello , May, 2014

Some patients are unable to generate the peak inspiratory flow rate (PIFR) necessary to de-agglomerate drug particles from dry powder inhalers (DPIs). In this study we tested the hypothesis that the acoustic parameters of an inhalation are related to the PIFR and hence reflect drug delivery....

Incidence, Event Rates, and Early Outcome of Stroke in Dublin, Ireland: The North Dublin Population Stroke Study.

by P.J. Kelly, G Crispino, O Sheehan, L Kelly, M Marnane, A Merwick, N Hannon, D Ní Chróinín, E Callaly, D Harris, G Horgan, E B. Williams, J Duggan, L Kyne, P McCormack, E Dolan, D Williams, J Moroney, C Kelleher, and L Daly, 2012

The World Health Organization has emphasized the importance of international population-based data for unbiased surveillance of stroke incidence and outcome. To date, few such studies have been conducted using recommended gold-standard ascertainment methods. We conducted a large, population-based stroke study in Dublin, Ireland ...